National Centre for Asbestos Related Diseases

Centre for Research Excellence in asbestos related diseases - National Centre for Asbestos Related Diseases

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Asbestos causes a range of diseases including the fatal cancer malignant mesothelioma (MM). Our team has studied asbestos-related disease for the past 20 years.

National Health and Medical Research Council 1001020, Chief Investigator A – Bruce Robinson

In 2006, enabled by the NHMRC and the Commonwealth, we formed the National Centre for Asbestos Related Diseases (NCARD). Since its founding the Centre has established strong leadership and collaborative structures in all States, and developed a world-class program of research. This application is from a team that includes many of the founding members of NCARD to continue and expand on the successful NCARD foundations.

The research component of the application focuses on three key areas: improving diagnosis, early intervention strategies, and improving treatment. We have strong preliminary data in each area, and a track record of translating research findings. Our previous work triggered commercialisation of an assay for the biomarker mesothelin in MM. We have worked with the asbestos-exposed Wittenoom population for over 20 years and conducted cancer prevention studies with this cohort. We have developed a rapid asbestos-inducible transgenic mouse model system to enable testing of new intervention strategies.

We have performed over 15 phase I and II clinical trials of novel therapeutic strategies, including studies that resulted in use of gemcitabine and cisplatin as the previous standard of care for MM.

 
 

National Centre for Asbestos Related Diseases

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Last updated:
Tuesday, 1 December, 2015 1:25 PM

http://www.ncard.uwa.edu.au/2638110